Unprecedented disruptions caused by the COVID-19 pandemic, followed by social, economic, geopolitical and environmental challenges, continue to place complex and interconnected threats on health and healthcare systems. But the past few years have also allowed for innovation in the way health and healthcare systems are designed and delivered. Now is the time to take forward key learnings from the pandemic response and align stakeholders, industries, countries, and sectors to a shared vision for health and healthcare by 2035.